Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)
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چکیده
منابع مشابه
Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation
Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30-120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K+ channels and volume-sensitive outwardly rectifying (VSOR) Cl- channels in a manner independent of caspase-3 activation. However, it is controvers...
متن کاملDual response of human leukemia U937 cells to hypertonic shrinkage: initial regulatory volume increase (RVI) and delayed apoptotic volume decrease (AVD).
BACKGROUND/AIMS Osmotic cell shrinkage is a powerful trigger of suicidal cell death or apoptosis, which is paralleled and enforced by apoptotic volume decrease (AVD). Cells counteract cell shrinkage by volume regulatory increase (RVI). The present study explored the response of human U937 cells to hypertonic solution thus elucidating the relationship between RVI and AVD. METHODS Cell water, c...
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A method is described for measuring volume changes in single L6 myoblasts at a stage of proliferating "myoballs", which allows to follow volume changes on single cell level by means of quantitative video image analysis. Myoblasts exposed to hypoosmotic or hyperosmotic challenges for up to 3-5 min behave as osmometers. The relative cell volume is a linear function of the reciprocal of the relati...
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Rat thymocytes displayed robust regulatory volume decrease (RVD) when suspended in NaCl-based hypotonic Ringer solutions. The RVD of thymocytes was completely abolished upon replacement of external Na+ ions with K+, indicating a role of coupled efflux of K+ and Cl- ions as a driving force of regulatory volume decrease. Osmotic water permeability (Pf) measured in KCl-based hypotonic solutions wa...
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【摘要】 研究背景 细胞在新陈代谢和完成各种生理功能过程中,不断面临着细胞内外渗透活性分子在细胞内外的流动,从而不断产生细胞内外渗 透压的变化,使细胞处于不断变化的渗透梯度中。由于细胞对水的自由通透性,水分会依据渗透梯度通过渗透或水通道流入或流出细胞,从而产生 细胞容积的变化。可见既使在正常生理条件下,细胞的容积也处于不断的变化中,与此相适应,许多细胞进化了自身的细胞容积调节功能,即当细 胞受到非等渗刺激而产生容积增大或缩小时,细胞自身会通过调节机制使变化了的细胞容积向正常体积恢复。细胞的容积调节功能在细胞的免疫应 答、细胞的迁移、细胞的增殖与分化过程中具有十分重要的意义。 细胞的容积调节功能主要包括两种:一种为调节性细胞容积增大(regulatory vol ume increase,RVI),指当细胞受到高渗透压的刺激而皱缩后,细胞能够调节性的使已经皱缩的细胞体积向正常体积恢复;...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2001
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.2001.0003g.x